Archive for January, 2008

Allegra and Fruit Juices

Thursday, January 31st, 2008

Fruit juices such as grapefruit, orange and apple may reduce the bioavailability and exposure of fexofenadine. This is based on the results from 3 clinical studies using histamine induced skin wheals and flares coupled with population pharmacokinetic analysis. The size of wheal and flare were significantly larger when fexofenadine hydrochloride was administered with either grapefruit or orange juices compared to water. Based on the literature reports, the same effects may be extrapolated to other fruit juices such as apple juice. The clinical significance of these observations is unknown. In addition, based on the population pharmacokinetics analysis of the combined data from grapefruit and orange juices studies with the data from a bioequivalence study, the bioavailability of fexofenadine was reduced by 36%. Therefore, to maximize the effects of fexofenadine, it is recommended that Allegra tablets should be taken with water

DOSAGE FORMS AND STRENGTHS

Thursday, January 17th, 2008

Allegra tablets are available in 30 mg, 60 mg, and 180 mg strengths. Allegra tablets are coated with a peach colored film coating. Tablets have the following unique shape and identifiers: 30 mg tablets are round, bi-convex and have 03 on one side and a scripted“e” on the other; 60 mg tablets are oval, bi-convex and have 06 on one side and a scripted “e” on the other; and 180 mg tablets are oblong, bi-convex and have 018 on one side and a scripted “e” on the other.

Allegra ODT is available as a 30 mg orally disintegrating tablet and is white, flat-faced, ½-inch round shaped with beveled edges and debossed with a scripted “e” on one side and “311AV” on the other side.

Allegra oral suspension is available as 30 mg/ 5 mL (6 mg/mL).

Recommended dosage

Saturday, January 5th, 2008

Adults and Children 12 Years and Older

For hay fever, the usual dosage is 60 milligrams twice a day or 180 milligrams once a day. For hives, it’s 60 milligrams twice a day. If you have kidney problems, your doctor may have you take only one 60-milligram dose daily.

Children 6 through 11 years old

For hay fever or hives, the usual dosage is 30 milligrams twice a day. Children with kidney problems may be prescribed only one 30-milligram dose each day.